Haploidentical allogeneic stem cell transplantation with post-transplant cyclophosphamide and subsequent kidney transplant for patients with severe sickle cell disease with end-stage kidney disease (ESKD)
Alexandra Gomez-Arteaga, Nina Orfali, Michelle Pasciolla, Ayanna Baptiste, Inna Guindine, Jingmei Hsu, Jonathan Lin, Sebastian A Mayer, Adrienne A Phillips, Tsiporah B Shore, Paul D Simonson, Edward DiCarlo, Sung Yoon, Thangamani Muthukumar, Koen van Besien...
Racial and Neighborhood-Level Disparities in COVID-19 Incidence among Patients on Hemodialysis in New York City
Sri Lekha Tummalapalli, Jeffrey Silberzweig, Daniel Cukor, Jonathan T Lin, Tarek Barbar, Yao Liu, Kwan Kim, Thomas S Parker, Daniel M Levine, Said A Ibrahim...
J Am Soc Nephrol. 2021 Aug;32(8):2048-2056. doi: 10.1681/ASN.2020111606. Epub 2021 Jun 3.
ABSTRACT
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has disproportionately affected socially disadvantaged populations. Whether disparities in COVID-19 incidence related to race/ethnicity and socioeconomic factors exist in the hemodialysis population is unknown.
METHODS: Our study involved patients receiving in-center hemodialysis in New York City. We used a validated index of neighborhood social vulnerability, the Social Vulnerability Index (SVI), which comprises 15 census tract-level indicators organized into four themes: socioeconomic status, household composition and disability, minority status and language, and housing type and transportation. We examined the association of race/ethnicity and the SVI with symptomatic COVID-19 between March 1, 2020 and August 3, 2020. COVID-19 cases were ascertained using PCR testing. We performed multivariable logistic regression to adjust for demographics, individual-level social factors, dialysis-related medical history, and dialysis facility factors.
RESULTS: Of the 1378 patients on hemodialysis in the study, 247 (17.9%) developed symptomatic COVID-19. In adjusted analyses, non-Hispanic Black and Hispanic patients had significantly increased odds of COVID-19 compared with non-Hispanic White patients. Census tract-level overall SVI, modeled continuously or in quintiles, was not associated with COVID-19 in unadjusted or adjusted analyses. Among non-Hispanic White patients, the socioeconomic status SVI theme, the minority status and language SVI theme, and housing crowding were significantly associated with COVID-19 in unadjusted analyses.
CONCLUSIONS: Among patients on hemodialysis in New York City, there were substantial racial/ethnic disparities in COVID-19 incidence not explained by neighborhood-level social vulnerability. Neighborhood-level socioeconomic status, minority status and language, and housing crowding were positively associated with acquiring COVID-19 among non-Hispanic Whites. Our findings suggest that socially vulnerable patients on dialysis face disparate COVID-19-related exposures, requiring targeted risk-mitigation strategies.
Characteristics of Acute Kidney Injury in Hospitalized COVID-19 Patients in an Urban Academic Medical Center
John R Lee, Jeffrey Silberzweig, Oleh Akchurin, Mary E Choi, Vesh Srivatana, Jonathan Lin, Frank Liu, Line Malha, Michelle Lubetzky, Darshana M Dadhania, Divya Shankaranarayanan, Daniil Shimonov, Sanjay Neupane, Thalia Salinas, Aarti Bhasin, Elly Varma, Lorenz Leuprecht, Supriya Gerardine, Perola Lamba, Parag Goyal, Eric Caliendo, Victoria Tiase, Rahul Sharma, Joel C Park, Peter A D Steel, Manikkam Suthanthiran, Yiye Zhang...
Clin J Am Soc Nephrol. 2021 Feb 8;16(2):284-286. doi: 10.2215/CJN.07440520. Epub 2020 Sep 18.
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